Coronary artery disease
Conditions
Interventions
None listed
Sponsors
Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: *Acute coronary syndrome 1. Patients who are over 20 years old at the time of obtaining consent 2. Patients diagnosed or suspected of ST-elevation myocardial infarction, non-ST-elevation myocardial infarction, or unstable angina 3. Patients who have received sufficient explanation for participation in this study, and who have fully understood and agreed to the document by their own free will. * Stable coronary artery disease group 1. Patients who are over 20 years old at the time of obtaining consent 2. When coronary artery stenosis is recognized as moderate or higher by coronary angiography or coronary CT 3. Patients diagnosed with coronary artery disease from 2 above 4. Patients who have received sufficient explanation for participation in this study, and who have fully understood and agreed to the document by their own free will. * Non-coronary artery disease group 1. Those who are 20 years of age or older when obtaining consent 2. Patients with suspected coronary artery disease who have no stenotic lesions on coronary CT or coronary catheterization 3. Parsons who have received sufficient explanation for participation in this study, and who have fully understood and agreed to the document by their own free will.
Exclusion criteria
Exclusion criteria: 1. Patients who may become pregnant 2. Patients who cannot obtain written consent 3. For those with acute coronary syndrome, those who have judged that it is inappropriate to safely undergo 18F-FDG PET / CT (decompensated heart failure) 4. Diabetic patients receiving continuous subcutaneous insulin infusion therapy, or patients who are considered unable to fast for 18 hours. 5. Other persons who are deemed inappropriate by the research supervisor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is to compare FDG accumulation (average value of the continuous amount of TBR) of plaque lesions by 18F-FDG PET / CT in patients with acute coronary syndrome, stable coronary artery disease group, and non-coronary artery disease group and to clarify the TBR value in patients with acute coronary syndrome. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Comparison of blood biomarkers (high-sensitivity CRP, endothelin 1, serotonin, MMP, interleukin 6, TBARS, etc.) between acute coronary syndrome group, stable coronary artery disease group, and non-coronary artery disease group. 2. Evaluation of correlation between the TBR (continuous dose) in coronary lesions and that in carotid lesions. 3. Evaluation of TBRs (continuous dose) before and after optical medical treatment in accordance with the guidelines for each group of acute coronary syndrome and stable coronary artery disease. 4. Examination of association between TBRs in coronary artery or carotid artery (before and after continuous dose and cutoff value) and prognosis. 5. Evaluation of predictors of TBR among variables (age, sex, diabetes history, hypertension history, dyslipidemia history, smoking history, myocardial infarction history, coronary revascularization history, blood LDL, HDL, high sensitivity CRP, troponin T and I, IL- 6, endothelin-1, MMP, serotonin, coronary stenosis, etc.). 6. Estimation of the cutoff value of TBR to distinguish acute coronary syndrome from stable coronary artery disease. | — |
Countries
Japan
Contacts
Public ContactMasanao Naya
Hokkaido University Hospital Cardiovascular Medicine
Outcome results
None listed