Clinical Outcomes of Japanese Patients with Coronary Artery Disease Assessed by Resting Indices and Fractional Flow Reserve: A Prospective Multicenter Registry

Clinical Outcomes of Japanese Patients with Coronary Artery Disease Assessed by Resting Indices and Fractional Flow Reserve: A Prospective Multicenter Registry - J-PRIDE Registry

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000038403

Enrollment

3000

Registered

2019-11-01

Start date

2019-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Age >=20 years old (2) Patients were clinically suspected of angina pectoris and underwent coronary angiography (CAG). (3) CAG showed more than 50% stenosis by visual estimation. (4) Both FFR and resting indices were performed to assess functional significance of coronary artery lesion. (5) Cases with iFR, RFR, dFR, or DFR as resting indices.

Exclusion criteria

Exclusion criteria: (1) culprit lesion of acute coronary syndrome (2) graft lesion (3) overt heart failure (4) inability to give informed consent

Design outcomes

Primary

Measure	Time frame
To compare 1-year TVF (target vessel failure) rate between four groups: (I) FFR <=0.80 and RI >0.89, (II) FFR >0.80 and RI <=0.89, (III) FFR >0.80 and RI >0.89, and (IV) FFR <=0.80 and RI <=0.89	—

Secondary

Measure	Time frame
1) To assess the feasibility of dPR, RFR, and DFR as compared with FFR and iFR 2) To compare 5-year TVF (target vessel failure) rate between four groups: (I) FFR <=0.80 and RI >0.89, (II) FFR >0.80 and RI <=0.89, (III) FFR >0.80 and RI >0.89, and (IV) FFR <=0.80 and RI <=0.89 3) To investigate the diagnostic accuracy between post-PCI FFR and RI values 4) To investigate the clinical impact of post-PCI FFR and RI values 5) To investigate the relationship between angiographic findings and physiological indices (FFR and RI) 6) To investigate cutoff points of RI for predicting future clinical events 7) To establish the algorithm using FFR, RI, and QFR (quantitative flow ratio) for ischemic diagnosis 8) To investigate the relationship between CCTA (coronary computed tomographic angiography) findings and physiologic indices (FFR and RI) 9) To investigate cutoff points of FFR and RI for predicting future clinical events associated with non-culprit lesions in patients with acute coronary syndrome 10) To investigate cutoff points of FFR and RI for predicting future clinical events in patients with aortic stenosis 11) To investigate cutoff points of FFR and RI for predicting future clinical events in dialysis patients 12) To investigate the relationship between FFR and RI in terms of diagnostic accuracy and clinical outcomes according to cardiac function. 13) To investigate the relationship between hyperemic agents and clinical outcomes 14) To investigate the relationship between pressure-derived coronary flow reserve, FFR, and RI	—

Measure

Time frame

1) To assess the feasibility of dPR, RFR, and DFR as compared with FFR and iFR 2) To compare 5-year TVF (target vessel failure) rate between four groups: (I) FFR <=0.80 and RI >0.89, (II) FFR >0.80 and RI <=0.89, (III) FFR >0.80 and RI >0.89, and (IV) FFR <=0.80 and RI <=0.89 3) To investigate the diagnostic accuracy between post-PCI FFR and RI values 4) To investigate the clinical impact of post-PCI FFR and RI values 5) To investigate the relationship between angiographic findings and physiological indices (FFR and RI) 6) To investigate cutoff points of RI for predicting future clinical events 7) To establish the algorithm using FFR, RI, and QFR (quantitative flow ratio) for ischemic diagnosis 8) To investigate the relationship between CCTA (coronary computed tomographic angiography) findings and physiologic indices (FFR and RI) 9) To investigate cutoff points of FFR and RI for predicting future clinical events associated with non-culprit lesions in patients with acute coronary syndrome 10) To investigate cutoff points of FFR and RI for predicting future clinical events in patients with aortic stenosis 11) To investigate cutoff points of FFR and RI for predicting future clinical events in dialysis patients 12) To investigate the relationship between FFR and RI in terms of diagnostic accuracy and clinical outcomes according to cardiac function. 13) To investigate the relationship between hyperemic agents and clinical outcomes 14) To investigate the relationship between pressure-derived coronary flow reserve, FFR, and RI

—

Countries

Japan

Contacts

Public ContactShoichi Kuramitsu

Sapporo Cardio Vascular Clinic Cardiovascular Medicine

kuramitsu@heart-kizuna.com0117847847

Outcome results