Yokohama Add-on Inhibitory Efficacy of Dapagliflozin on Left Ventricular Filling Pressure in Patients with Acute Heart Failure with Preserved Ejection Fraction Complicated with type 2 Diabetes Study

Yokohama Add-on Inhibitory Efficacy of Dapagliflozin on Left Ventricular Filling Pressure in Patients with Acute Heart Failure with Preserved Ejection Fraction Complicated with type 2 Diabetes Study - D-HFPEF

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000038380

Enrollment

Registered

2019-10-25

Start date

2016-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute heart filure with preserved ejection fraction complicated with type 2 diabetes mellitus

Interventions

Dapagliflozin for 12 weeks Alogliptin for 12 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ADHF with HFpEF complicated with type 2 DM. EF>=40% and stable hemodynamically. (1)>/=20years old. (2)type 2 Dm; HbA1c6.5-11.0% (similar to EXAMINE trial) (3)LVEF>/=40% (4)agreement with papers (5)stable state

Exclusion criteria

Exclusion criteria: (1)type1 DM (2)pregnancy (3)CKD stage4, 5 (4)CPK>3 folds of normal range (5)hepatic injury (6)NYHA4, oxygenation, intravenous treatment (7)diabetic ketoacidosis (8)serious infection (9)systemic anesthesia, post surgery (10)sensitive for dapaglifrozin or allogiptin (11)SGLT2 inhibitor or Dpp4 inhinitor, but they are applicable if in case HbA1c control is not good (12)incapable controllable DM (13)pregnancy (14)if clinician thinks they are not applicable

Design outcomes

Primary

Measure	Time frame
Diastolic parameters of echocardiography after 12 weeks ; including left ventricular filling pressure	—

Secondary

Measure	Time frame
BNP, Cr, eGFR, Urinalysis, Endopat, PWV, events	—

Countries

Japan

Contacts

Public ContactMayumi Ninomiya

Yokohama city university medical center Division of cardiology

ninomayu@yokohama-cu.ac.jp045-261-5656

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026