gastric cancer
Conditions
Interventions
8 courses of S-1 chemotherapy
Sponsors
Takatsuki general hospital
Graduate School of Medicine, Kyoto University Japanese Red Cross Wakayama Medical Center Kobe City Medical Center General Hospital Hyogo Cancer Center Gastrointestinal Center, SANO HOSPITAL Akashi Medical Association Akashi Medical Center Ise Red Cross Hospital Kobe University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients underwent non curative ESD for gastric cancer who refuse additional gastrectomy 2) Age from 20 to 85 years old 3) European Cooperative Oncology Group(ECOG) performance status of 0 or 1 4) No previous treatment of chemotherapy or radiation therapy for any neoplasms 5) Enough oral intake 6) Preserved organ function as follows 1 neutrophile count >=1,500/mm3 2 hemoglobin >=8.0 g/dL 3 platelet count >=75,000/mm3 4 AST=<100 IU/L 5 ALT=<100 IU/L 6 total bilirubin =<2.0 mg/dL 7 creatinine clearance (CCr) >=40 mL/min 7) Written informed consent
Exclusion criteria
Exclusion criteria: 1)Synchronous double/multiple cancer or metachronous double/multiple cancer with progression free period of 5 years or shoter, except mucosal cancer treated by endoscopic resection 2) previous gastrectomy 3) Infection requiring systemic treatment 4) Women expecting pregnancy, in pregnancy, in possible pregnancy or in breast feeding 5) Male expecting partner's pregnancy 6) Severe mental disease 7) Under treatment by flucytosine, phenytoin, or warfarin potassium 8) Uncontrolled diabetes mellitus 9) severe lung disease (Interstitial pneumonia, severe emphysema and so on) 10) unstable angina or myocardial infarction within 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse-free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival, Disease specific survival, Rate of treatment continuation, Adverse event | — |
Countries
Japan
Contacts
Public ContactHiroaki Sawai
Takatsuki general hospital Division of Gastroenterology
Outcome results
None listed