An observational study of the background, treatment status, and prognosis of patients with severe septic shock

Conditions

Severe septic shock

Miyamoto K, Kawazoe Y, Miyagawa N, Yamamura H, Ohta Y, Kimura T, Toyoda Y, Kyo M, Sato T, Kinjo M, Takahashi M, Maruyama J, Matsuura H, Fukushima K, Morimoto T, BEAT‐SHOCK Registry Investigator.

2025-10-09

10.1111/aor.70025

Early Rehabilitation for Patients with Septic Shock Associated with Mobilization During Their Intensive Care Unit Stay Without Worsening Mortality: A Multicenter, Prospective, Cohort Study

Tasuku Hanajima, Yu Kawazoe, Takeshi Morimoto, Hitoshi Yamamura, Kyohei Miyamoto et al. (13 authors)

Journal of Intensive Care Medicine2025-07-04

10.1177/08850666251355211

HEMODYNAMIC RESPONSE BY POLYMYXIN B HEMOPERFUSION AND ITS CLINICAL OUTCOMES IN PATIENTS WITH REFRACTORY SEPTIC SHOCK: A POST-HOC SUBANALYSIS OF PROSPECTIVE COHORT STUDY

Kyohei Miyamoto, Yu Kawazoe, Noriko Miyagawa, Hitoshi Yamamura, Yoshinori Ohta et al. (21 authors)

Shock2025-06-171 citations

10.1097/shk.0000000000002654

Time to administer polymyxin B hemoperfusion and hemodynamics in patients with septic shock requiring high-dose norepinephrine: a predetermined analysis of a prospective cohort study

Kyohei Miyamoto, Yu Kawazoe, Noriko Miyagawa, Hitoshi Yamamura, Yoshinori Ohta et al. (21 authors)

Critical Care2025-05-093 citations

10.1186/s13054-025-05422-7

Interventions

None listed

Sponsors

Tohoku University Graduate School of Medicine Division of Emergency and Critical Care Medicine

Lead Sponsor

Hokkaido University Hospital Department of Emergency Medicine, Iwate Medical University, Fukushima Medical University Hospital, Gunma University Hospital, Tokyo Women&#39

Collaborator

s Medical University Adachi Medical Center, Saiseikai Utsunomiya Hospital, Saiseikai Yokohamashi Tobu Hospital, Kitasato University Hospital, Nagoya Medical Center, Osaka Prefectural Nakakawachi Emergency and Critical Care Center, Nara Prefecture General Medical Center, Wakayama Medical University, Okayama University, Hiroshima University, Kagawa University, Ehime University Hospital, Fukuoka University, University of Occupational and Environmental Health, Saga University, National Hospital Orga

Collaborator

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients 18 years of age or older admitted to the intensive care unit after July 2019 2) Septic shock patients: need a vasopressor to maintain blood pressure >=65 mmHg after infusion, and sustained high lactate >2 mmol/L 3) Noradrenaline (dose >=0.2 gamma) administered within 24 hours after diagnosis of sepsis

Exclusion criteria

Exclusion criteria: 1) Cases of ICU discharge and death within 48 hours of enrollment 2) Patients with a limited long-term prognosis due to coexisting malignancy 3) Cases in which new organ damage had already preceded the onset of sepsis 4) Acute myocardial infarction, heart disease (New York Heart Association[NYHA]4) 5) Severe chronic liver disease (Child-Pugh C) 6) Attending physician's decision 7) Opt-out applicant by patient or proxy consenter

Design outcomes

Primary

Measure	Time frame
28-day mortality	—

Secondary

Measure	Time frame
ICU mortality 90-day mortality Duration of mechanical ventilation Length of stay in the ICU 90-day reintegration 90-day degree of care(Barthel Index) 90-day short-term memory score(Short Memory Questionnaire) PTSD associated with ICU treatment(Impact of Event Scale-reviced) etc.	—

Countries

Japan

Contacts

Public ContactYu Kawazoe