Healthy volunteers
Conditions
Interventions
Group 1: 1 course to 2 course 2 Intake Conditions Crossover 1 Course (medium-dose intakes between meals) 2 Course (low-dose intakes before meals)
Group 2: 2 course to 1 course 2 Intake Con
Sponsors
SOUSEIKAI Sumida Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy male and female subjects who are 40 years and older. Who can be participated in the study at designated times and places on the planned study dates. Who have provided with the documented consent by his/her own will after having received the thorough explanation and understand about the study participation.
Exclusion criteria
Exclusion criteria: Who has been commented on any cognitive declines or diagnosed with dementia from physicians. Who is under treatment for any life style related disease such as Diabetes Mellitus, Hyperlipidemia, or Hypertension. Who is under medication. Who has cancer (diagnosis and under treatment), or is within 5 years after the completion of cancer treatment. Who has current diseases such as Cirrhosis, Renal failure, congenital metabolic disease of amino acids or who is on Hemodialysis. Who has a history of surgery on any digestive organs or liver, gall bladder, pancreas. (Appendectomy is acceptable) Who has Alcohol dependency, nicotine dependency. Who has any food allergies or is lactose intolerant. Who has anemia, malnutrition, or viral diseases or any serious diseases or symptoms. Who has been taking any amino acids or protein enhancement food/supplements within 1 month from the first consumption of the study food. Who has taken more than 200 mL of blood within 1 month. Who is currently participating in any other studies that involves using any foods, cosmetics or medications. Who has been confirmed any abnormal clinical values of the level of [Medical Consultation needed] at a screening test. Who has been considered ineligible by the study doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyze the changes of amino acid concentrations in the blood. (Amino acids to be analyzed; those included in the test food, those not included in the test food, the metabolites.) To simulate the inflow speed of amino acids and the metabolites using the uptake kinetics of amino acid transporters that are being expressed on human BBB based on the changes of blood amino acid concentrations. | — |
Countries
Japan
Contacts
Public ContactTomoyuki Tagami
Ajinomoto Co.,Inc. Research Inst. Bioscience Product & Fine Chemicals
Outcome results
None listed