Assessment of the postoperative analgesic efficacy of periodic intravenous administration of acetaminophen after gynecologic laparoscopic surgery

Assessment of the postoperative analgesic efficacy of periodic intravenous administration of acetaminophen after gynecologic laparoscopic surgery - Periodic intravenous acetaminophen administration versus intravenous patient-controlled analgesia of fentanyl (gynecologic laparoscopic surgery)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000038175

Enrollment

120

Registered

2019-10-01

Start date

2019-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

uterine disease

Interventions

Periodic administration of acetaminophen dose:1000 mg (body weight over 50kg) or 15 mg/kg (body weight less than 50kg) timing:Primary dosage is administrated 30 minutes before the end of surgery and

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1)Patients who weigh over 40 kg and less than 100 kg 2)Patients who undergo laparoscopic hysterectomy 3)Patients without liver dysfunction(AST>100IU/l,ALT>100IU/l.T-bil>1.8mg/dl) 4)Patients without renal dysfunction(CCr or eGFR<60ml/min) 5)Patients without allergy to acetaminophen, opioid and local anesthetics

Exclusion criteria

Exclusion criteria: 1)Patients who weigh less than 40 kg and over 100 kg 2)Pregnant patients 3)Patients with nervous, heart, respiratory complications 4)Patients with allergy to acetaminophen, opioid and local anesthetics 5)Patients taking antipsychotics 6)Patients with liver and renal dysfunction 7)Patients who cannot understand pain scale 8)Patients who cannot obtain agreements 9)Patients who need additional open incision

Design outcomes

Primary

Measure	Time frame
Frequency of supplemental or rescue analgesic administration for 24 hours postoperatively	—

Secondary

Measure	Time frame
1)the pain score (numerical rating scale: NRS) at rest at 6, 12 and 24 hours postoperatively 2)satisfaction of the patient at 24 hours postoperatively 3)frequency of nausea and vomiting for 24 hours postoperatively 4)frequency of antiemetic administration for 24 hours postoperatively	—

Countries

Japan

Contacts

Public ContactNamiko Hashimoto

Nippon Life Hospital Obstetrics and Gynecology

namikosaka@aol.com06-6443-3446

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026