Esophageal cancer
Conditions
Interventions
Cardiac MRI is performed before and 6 mpnths after intensity-modulated radiation therapy.
Sponsors
Department of Radiation Oncology, Tohoku University, Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Esophageal cancer diagnosed histologically by biopsy. (2) Cases scheduled for definitive radiation therapy with T1N0M0 (UICC-TNM 8th edition). (3) Cases in which a part of the heart is assumed to be included in the radiation field. (4) Eastern Cooperative Oncology Group performance status, 0-1. (5) Normal kidney function (estimated glomerular filtration rate [eGFR] > 30 ml/min/1.73m2). (6) There is written consent of the patient.
Exclusion criteria
Exclusion criteria: (1) Cases with heart disease and hypertension taking ACE inhibitor / ARB. (2) Cases with serious complications other than heart disease (uncontrolled lung / liver / kidney disease, diabetes, collagen disease, intestinal obstruction, active ulcer of the digestive tract, etc.). (3) Cases with active malignancy other than esophageal cancer. (4) Cases with a history of chemotherapy. (5) Cases with history of mediastinal irradiation. (6) Cases scheduled for radiation therapy alone (7) Female during pregnancy, within 28 days of postparturition, or during lactation (8) Cases with pacemakers or internal metal implants (9) Claustrophobia (10) Severe psychological disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of myocardial changes on cardiac MRI six months after intensity-modulated radiation therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative incidence of cardiac accident after intensity modulated radiation therapy | — |
Countries
Japan
Contacts
Public ContactRei Umezawa
Tohoku University Hospital Department of Radiation Oncology
Outcome results
None listed