Epigenome-wide association study identifies a novel DNA methylation in patients with severe aortic valve stenosis

Epigenome-wide association study identifies a novel DNA methylation in patients with severe aortic valve stenosis - Epigenome-wide association study identifies a novel DNA methylation in patients with severe aortic valve stenosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000038129

Enrollment

200

Registered

2019-09-27

Start date

2014-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patient of aortic valve stenosis and health people

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Symptomatic AS, An aortic valve area of < 1.0 cm2, An aortic valve area index of < 0.6 cm2/m2, Mean aortic gradient > 40 mmHg or peak aortic velocity > 4 m / second

Exclusion criteria

Exclusion criteria: clinical signs of acute coronary syndrome, acute infection, severe renal failure (serum creatine levels over 3 mg/dL) or rheumatoid disease, or if they were suspected of having a malignant or primary wasting disorder

Design outcomes

Primary

Measure	Time frame
identifies a novel DNA methylation in patients with severe aortic valve stenosis	—

Countries

Japan

Contacts

Public ContactTakahito Nasu

Iwate Medical University Division of Biomedical Information Analysis, Institute for Biomedical Sciences

tnasu@iwate-med.ac.jp+81-19-613-7111

Outcome results