Healthy person
Conditions
Interventions
Intake of NMN (253.8mg) every morning for 12 weeks (from getting up to 12 am)
Intake of NMN (253.8mg) every afternoon for 12 weeks (from getting up to 12 am (from 6pm to before bedtime)
Intake of plac
Sponsors
University of Tsukuba
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects with the capacity to participate the study-related briefing sessions, examinations and measurements in University of Tsukuba by themselves 2) Subjects without dementia, need for long-term care service, sleep disorders or regular intake of sleeping drugs(more than once a week) depression or regular intake of anti-depressants(more than once a week) 3) Subjects with a thorough understanding of this study, and voluntary consent
Exclusion criteria
Exclusion criteria: 1) Subjects with a regular intake of sleeping drugs or anti-depressants(more than once a week) 2) Subjects with an average intake of caffeine more than 400mg per day 3) Subjects with intake of supplements, nutrition drinks or energy drinks that contain NMN or niacin (Vitamin B3, nicotinamide, nicotinic acid amide) 4) Subjects with allergies to supplements, nutrition drinks or energy drinks that contain NMN or niacin(Vitamin B3, nicotinamide, nicotinic acid amide) 5) Subjects diagnosed with chronic fatigue syndrome, sleep disorders(insomnia), mental disorders such as depression, or alcoholism and under medical treatment 6) Subjects who correspond to Not at all in category of fatigue, poor sleep or stress based on 5 level evaluation (Not at all, Slightly, Moderately, Very much, Extremely) 7) Subjects who are involving in other clinical experiments currently or having participated any other clinical experiments in the past 3 months 8) Subjects excluded as inappropriate participants by the lead principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of Pittsburgh Sleep Quality Index(PSQI), Visual Analogue Scale(VAS) of evaluating physical fatigue and eye strain, Geriatric depression scale(GDS), Sense of Coherence(SOC) using questionnaires | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Physical performance tests: Grip strength, Five times sit to stand, Timed up and go, 5m habitual walk 2) Cognitive functions: Trail Making Peg, Five cognitive function test(attention, verbal memory, visuospatial cognition, word fluency, associate learning) | — |
Countries
Japan
Contacts
Public ContactMijin Kim
University of Tsukuba Industry-University Collaboration R&D Center for Tailor-Made QOL
Outcome results
None listed