Solute removal of hybrid online hemodiafiltration compared to pre-dilution online hemodiafiltration

Solute removal of hybrid online hemodiafiltration compared to pre-dilution online hemodiafiltration - Solute removal of hybrid online hemodiafiltration compared to pre-dilution online hemodiafiltration

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000038028

Enrollment

Registered

2019-09-25

Start date

2019-02-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease/dialysis patient

Interventions

Predilution OHDF (ABH-22PA) &gt

&gt

Washout period (2 hemodialysis) &gt

Hybrid OHDF (ABH-22PA) &gt

Predilution OHDF (ABH-22LA) &gt

Washout Period (2 hemodialysis) &gt

Hybrid OHDF (ABH-22LA)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients with albumin of 3.5 g/dL or more who have been undergoing chronic maintenance dialysis therapy between March 2019 to April 2019 at the Toujinkai Hospital.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Ten patients undergoing chronic maintenance dialysis therapy were included in this study. Four blood purification procedures were performed on the first day of each week's dialysis treatment: predilution OHDF using ABH-22LA (albumin leakage suppression type hemodiafilter), predilution OHDF using ABH-22PA (albumin leakage type hemodiafilter), hybrid OHDF using ABH-22LA, and hybrid OHDF using ABH-22PA. The dialyzed and filtered fluid drained during the 4-h session was collected and the concentrations of urea nitrogen, creatinine, inorganic phosphorus, beta2-microglobulin, alfa 1-microglobulin, and albumin were measured. From these, the removed amount and the clear space of each solute were calculated and were compared in hybrid OHDF and predilution OHDF.	—

Measure

Time frame

Ten patients undergoing chronic maintenance dialysis therapy were included in this study. Four blood purification procedures were performed on the first day of each week's dialysis treatment: predilution OHDF using ABH-22LA (albumin leakage suppression type hemodiafilter), predilution OHDF using ABH-22PA (albumin leakage type hemodiafilter), hybrid OHDF using ABH-22LA, and hybrid OHDF using ABH-22PA. The dialyzed and filtered fluid drained during the 4-h session was collected and the concentrations of urea nitrogen, creatinine, inorganic phosphorus, beta2-microglobulin, alfa 1-microglobulin, and albumin were measured. From these, the removed amount and the clear space of each solute were calculated and were compared in hybrid OHDF and predilution OHDF.

—

Countries

Japan

Contacts

Public ContactNaoki Suzuki

Toujinkai Hospital Clinical Engineering

suzuki@tojinkai.jp075-622-1991

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026