Agitation in the intensive care unit
Conditions
Interventions
Administration of zotepine 25-50 mg at a time, additional dose can be given 8 hours later.
Administration of quetiapine 25-50 mg at a time, additional dose can be given 8 hours later.
Sponsors
Pharmaceutical Department, JA Hiroshima General Hospital and Division of Emergency and Critical Care Medicine, JA Hiroshima General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 16 years old and more 2. Enteral nutrition can be administered 3. The physician considered the use of propofol newly in Richmond Agitation-Sedation Scale + 1 and more (agitation)
Exclusion criteria
Exclusion criteria: 1. Intensive Care Delirium Screening Checklist 3 and less 2. Admitted with a primary neurologic condition or injury (e.g., intracranial hemorrhage, active seizure) 3. History of hepatic encephalopathy or end-stage liver disease 4. Actively withdrawing from alcohol 5. Treatment with an antipsychotic agent in the 30 days before ICU admission 6. Current treatment with a neuromuscular blocker 7. Current treatment with an agent having either the potential to affect quetiapine concentrations (e.g., phenytoin) 8. Increase the risk for QTc prolongation 9. Baseline QTc interval 500 sec and more 10. Pregnancy 11. Non-Japanese speaking 12. Presence of a condition preventing of assessment Intensive Care Delirium Screening Checklist 13. Prognosis considered hopeless 14. Refused by the patient or family 15. The decision of physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with Intensive Care Delirium Screening Checklist < 4 on the next observation day following first dose | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with maximum blood glucose level 180 mg/dL or more for 24 hours after taking study drug | — |
Countries
Japan
Contacts
Public ContactShodai Yoshihiro
JA Hiroshima General Hospital Pharmaceutical Department
Outcome results
None listed