Association between carperitide infusion and shedding of the endothelial glydocalyx in non-cardiac surgery ICU patients

Association between carperitide infusion and shedding of the endothelial glydocalyx in non-cardiac surgery ICU patients - Carperitide infusion and shedding of the endothelial glycocalyx in non-cardiac surgery ICU patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000037975

Enrollment

Registered

2019-09-10

Start date

2020-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU patients except for post-cardiac surgery admittion who recieving carperitide infusion therapy

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients (except for post-cardiac surgery admission to ICU) who scheduled to start carperitide infusion therapy in ICU.

Exclusion criteria

Exclusion criteria: 1. A patient who have had recieved carperitide infusion within 12h 2. A patient with wobbly tooth 3. A patient with active bleeding in the mouth 4. A patient who have surgical history of tongue 5. A patient without any indwelling arterial line 6. A patient determined to be inappropriate as a research subject by the principal investigator

Design outcomes

Primary

Measure	Time frame
Change in Perfused Boundary Region (PBR) [Time frame: just before the start of carperitide infusion, 1h, 2h, 6h after the start of infusion]	—

Secondary

Measure	Time frame
Change in plasma syndecan-1 concentration, RBC column width, RBC filling [Time frame: just before the start of carperitide infusion, 1h, 2h, 6h after the start of infusion]	—

Countries

Japan

Contacts

Public ContactKazuyuki Mizunoya

Hokkaido University Hospital Anesthesiology

kazuyuki_mizunoya@hotmail.com011-716-1161

Outcome results