Healthy adults
Conditions
Interventions
Mixed vegetables and fruits juice (195 mL/day for 8 weeks)
Placebo (195 mL/day for 8 weeks)
Sponsors
Kagome CO., LTD.
CPCC Co., Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Healthy Japanese subjects 2) Subjects who notice themselves as they are mild/moderate perennial allergic rhinitis. 3) Subjects who have positive results on serum allergen-specific IgE against house dust or mites. 4) Subjects who are judged suitable for this study by principal investigator.
Exclusion criteria
Exclusion criteria: 1) Subjects who have positive results on serum allergen-specific IgE against Poaceae or Ambrosia artemisiifolia and are judged that symptoms of allergic rhinitis depend on their antigen. 2) Subjects who have non-allergic rhinitis 3) Subjects who have acute rhinitis, sinusitis, nasal polyp, hypertrophic rhinitis, and deviated septum. 4) Subjects who take medicines such as anti-histamine and anti-allergy. 5) Subjects who have bronchial asthma as a complication. 6) Subjects who currently receive or have previously received allergen immunotherapy. 7) Subjects who have current medical history of serious disease in heart, liver, kidney and digestive system. 8) Subjects who have previous medical history of serious disease and be judged unsuitable for this study by principal investigator. 9) Subjects who will be treated or take medicine for perennial allergic rhinitis during this study period. 10) Subjects who have vegetables-based diet 11) Subjects who intake the medicines, the foods for specified health uses and/or the health foods that are concerned their influence to test results. 12) Pregnant or expected pregnant, planning pregnant during this study period and lactating women 13) Subjects who cannot take test food and record diary as instructions. 14) Subjects who habitually consume higher amount of alcohol (=> 60 g alcohol/day) 15) Subjects with risk of allergy regarding to this study 16) Subjects who are participating in the other clinical tests. Subjects who participated in the other clinical tests within 2-months prior to this study and/or who plan to participate in the other clinical tests. 17) Subjects who donated over defined blood and/or blood components amounts before this study. 18) Subjects who are judged unsuitable for this study by principal investigator and doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal symptom score(Record score using a 5-point scale) before and 2, 4, 6, 8 weeks after the intervention with mixed vegetables and fruits juice or placebo. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nasal symptom score (Japan Rhinoconjunctivitis Quality of Life Questionnaire (JRQLQ)), Ocular symptom score, QOL score (JRQLQ), non-specific IgE, Allergen-specific IgE, eosinophil count in nasal discharge, Serum carotenoid concentrations | — |
Countries
Japan
Contacts
Public ContactSuguru Fujiwara
CPCC Co., Ltd. Clinical Research Department
Outcome results
None listed