Healthy adult
Conditions
Interventions
Ingestion of capsules including mixed plant extract once a day for 12 weeks.
Ingestion of capsules not including mixed plant extract once a day for 12 weeks.
Sponsors
TTC Co., Ltd
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: (1) Female ages 40 or more and less than 65 years old (2) Subjects with a lot of skin AGEs accumulation
Exclusion criteria
Exclusion criteria: (1)smoking subjects (2)subjects who have a habit of drinking more than 4 times a week (3)less than five hours in mean sleep (4)routinely taking foods or medicines which may affect skin or blood glucose (5)BMI more than 30 (6)treatment or a history of serious disease or affecting a secretion of sex hormones (7)diseases which affect this study (8)expected to be developed the allergy symptoms on skin (9)donated > 200 mL of blood within 1 month or > 400 mL within 3 months prior to the study (10)eat or drink too much during this trial, or who have a habit of eating out (11)treated cosmetic care (12)treated cosmetic care except for measuring sites, or hormonal therapy for one year (13)a facial, a wash-rag, lost hair on measuring sites for one month ago, or plans these actions (14)no habit of preventing sunburn (15)plan to have ultraviolet exposure within a month before the screening test (16)wash the body providing strong skin irritation (17)the skin chronic disease including atopic dermatitis (18)subjects who have the wound or inflammatory disease affecting the measuring skin (19)trouble by rough skin around a menstruates (20)subjects who work for anti-glycation foods related companies, or subjects who have family members working for such companies (21)employed on a pre-dawn shift or on night duty more than 2 times (22)planned to go overseas (23)possibilities for emerging allergy related to the study (24)judged as unsuitable for the study based on the results of clinical and physical examination on screening test (25)participated in other clinical study within the last one month prior to the current study or are planned to participate in other clinical study after informed consent for the current study (26)planned to become pregnant after informed consent for the current study or are pregnant or lactating (27)judged as unsuitable for the study based on the results of lifestyle questionnaire (28)judged as unsuitable for the study by the investigator for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate skin AGEs accumulation, internal body AGEs, skin wrinkles, HOMA-IR, AST and ALT when taking the study food continuously for 12 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate other cosmetic indicators, glucose metabolism and liver function items when the study food is continually consumed for 12 weeks. | — |
Countries
Japan
Contacts
Public ContactNaoki Matsuo
Karada Lab, Inc. No division
Outcome results
None listed