geriatric depression
Conditions
Interventions
The subjects are treated with antidepressant drugs in accordance with the Japan Depression Society Treatment Guidelines. PET 11C PBB3 555MBq PET 18F FE-PE2I 185MBq MRI
Sponsors
Nippon Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Subjects who are over 60 years old when obtaining consent - Subjects diagnosed with F3 by ICD-10 diagnostic criteria - Subjects who have received sufficient explanation for participation in this study, who can fully understand the subject and can obtain written consent based on his / her free will
Exclusion criteria
Exclusion criteria: - with past or current history of serious medical illness and/or brain organic diseases - subject who is contraindicated for the use of MRI - with past or current history ofsevere liver disease, kidney disease, heart disease, allergy, or severe drug allergy - pregnant women at the time of the research and those who are likely to become pregnant - subject who are judged as not suitable for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tau protein accumulation in brain and dopamine transporter binding potential in geriatric depression, and their changes over time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of higher brain function by neuropsychological tests Degree of atrophy by head MRI | — |
Countries
Japan
Contacts
Public ContactTakeshi Sakayori
Nippon Medical School Department of Neuropsychiatry
Outcome results
None listed