Allergy (Healthy volunteers)
Conditions
Interventions
diphenhydramine 50mg
levocetirizine 5mg
placebo
Sponsors
Tohoku University Cyclotron and Radioisotope Center
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Healthy volunteers 2) Performance Status (Grade 0) 3) ranging 20-25 years old 4) men 5) right-handed
Exclusion criteria
Exclusion criteria: 1) Subjects who take medications (including antihistamines) acting on histaminergic nervous systems and other targets 2) Subjects with abnormality in brain MRI images. 3) Subjects with past history of severe allergic reactions against drugs and foods as well as against chemicals (skin allergy etc.) 4) Subjects with past history of epilepsy 5) Subjects with moderate to severe glaucoma and uninary tract obstruction such as prostatic enlargement 6) Subjects with other disorders to which administration of anticholinergic and antihistaminergic treatment is not suitable 7) Subjects with moderate to severe abnormality in renal and liver functions 8) Subjects with past experiences of taking PEET examinations within 3 years of the present study as well as with other abnormalities, the investigators think the inclusion to this study is not suitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| regional cerebral blood flow during cognitive tests done after oral administration of antihistamines. | — |
Secondary
| Measure | Time frame |
|---|---|
| subjective sleepiness and performance in cognitive tests done after oral administration of antihistamines. | — |
Countries
Japan
Contacts
Public ContactManabu TASHIRO
Tohoku University Cyclotron and Radioisotope Center Division of Cyclotron Nulclear Medicine (a branch clinic of Tohoku University Hospital)
Outcome results
None listed