lifestyle-related disease
Conditions
Interventions
ketone ester
single
Sponsors
Sportology center, Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: BMI: 18.5 to 25.0 kg/m2 Persons who gained document consent by the patients' free intention after having sufficient explanation for participation in this study and having sufficient understanding
Exclusion criteria
Exclusion criteria: 1, history of diabetes 2, history of food allergy 3, history of drug hypersensitivity 4, habitual drinker (ethanol=>30g/day) 5, history of hypertension or dyslipidemia 6, history of digestive system disease 7, history of digestive surgical operation 8, history of hepatitis B virus or hepatitis C virus 9, history of hepatitis heart disease 10, liver dysfunction (AST,ALT:=>51U/L, gamma-GTP=>101U/L) or renal dysfunction (urinary protein2+,uric blood2+,creatinine level=>1,3mg/dl) 11, Recent weight changes or attempts to lose weight (3kg weight gain or loss, within last 1 month) 12, low-carbohydrate diet (carbohydrate under 150g/day) 13, current smoker 14, subjects judged unsuitable to the study from staff (ex, for MRI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The changes of blood glucose after ketone ester during oral glucose tolerance test (area under the curve) | — |
Secondary
| Measure | Time frame |
|---|---|
| After ketone ester during oral glucose tolerance test - beta hydroxybutyrate - acetoacetic acid - total ketone - insulin - C-peptide - glucagon - free fatty acid - incretin hormone - Insulinogenic Index - Matsuda Index | — |
Countries
Japan
Contacts
Public ContactNakagata Takashi
Juntendo University Sportology center
Outcome results
None listed