Nausea
Conditions
Interventions
Procedures: All subjects are asked to fast for at least for 4 h before the experiment. After placement of the EGG electrodes and VR head set machine, the subjects are asked to sit and relax on the ch
Sponsors
Teikyo Heisei University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Male aged 16 and under 30 2) Those who can attend the research site within the research period 3) Persons who can get written consent for participation in this study
Exclusion criteria
Exclusion criteria: 1) Patients who are hospitalized or taking medication for basic diseases (diabetes, heart disease, kidney disease, liver disease, hyponatremia, difficult to treat hypertension, etc.) 2) Persons receiving medication 3) Persons with extremely short sleep (less than 5 hours per day) and those with long sleep (over 10 hours per day) 4) Those who have a reverse life day and night due to work or part-time job 5) Persons receiving treatment for autoimmune diseases, chronic inflammatory diseases, allergic diseases, cancer 6) People who have a habit of excessive smoking * 1 and excessive alcohol consumption * 2 or who are extremely irregular in their diet 7) Persons with significant abnormalities in blood pressure, blood tests, urine tests, etc. 8) Persons suspected of acute infections such as influenza 9) Those who have undergone major surgery in the digestive system such as gastrectomy, gastrointestinal suture, and intestinal resection 10) 400ml blood donation within 12 weeks before the experiment, 200ml blood donation within 4 weeks, ingredient blood donation within 2 weeks 11) Participants in other clinical trials <Note> * 1 Excessive smoking refers to more than 21 smoking per day. * 2 Excessive alcohol consumption is more than 2 gos per day in terms of sake (500ml x 2 bottles of beer, 60ml x 2 whiskey doubles, 180ml mixed shochu, 60ml x 7 glasses of red wine glass) Refers to drinking alcohol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EGG recording and data analysis:Percutaneous EGG is applied to record gastric myoelectrical activity in sitting position. Disposable Ag-AgCl2 electrodes (Vitrode M, NIHON KODEN) are affixed to the abdominal wall. EGG recordings have performed with a portable EGG recorder (EGS2, Nipro Co., Japan) with low and high cutoff frequencies of 1 and 12 cpm. After completion of the recording, EGG data are digitized at a sampling rate of 1 Hz and transferred to a personal computer, then analyzed with a commercially available software program (EGS2, Version 1.31, Gram Corp., Tokyo, Japan). Using a fast Fourier transform (FFT), we compute an algorithm of a power spectra of every 256 s. Each EGG recording have divided into blocks of 60 s without overlapping. On the power spectrum of each 60 s, the dominant frequencies of EGG are defined under 9 cpm. The percentages of the normogastria range (2-4 cpm), the bradygastria range (0-2 cpm), and the tachygastria range (4-9 cpm) are calculated, respectively. The percentage of gastric dysrhythmia is defined as the percentage of time during which normogastria of 2-4 cpm slow waves are absent over the entire observation period. After placement of the EGG electrodes and virtual reality (VR) head set machine, the subjects have asked to sit and relax on the chair for a total of 45 min: 15 min baseline period, 15 min drum rotation with VR, and 15 min recovery period. EGG have continuously recorded before, during, and after the drum rotation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrodes are attached to the chest and amplified using a bio-amplifier (ML132, AD instruments). The filter settings are high cut filter 60 Hz and the time constant is 0.03 sec. The electrocardiogram is taken into a PC at a sampling rate of 1 kHz via an A / D converter (PowerLab 8sp, AD Instruments), and heart rate variability (HRV) analysis is performed every 5 minutes using the analysis software Chart5 (PowerLab, AD Instruments) and HRV module. In the power spectrum obtained by FFT analysis, the band of 0.05 to 0.15 Hz is used as the low frequency (LF) component as an index of sympathetic nerve function, and the band of 0.15 to 0.4 Hz is used as the high frequency (HF) component of parasympathetic nerve function. Find the ratio of LF to total power (LF normalized unit: LFnu) and the ratio of HF (HF normalized unit: HFnu).As an index of the relative balance between the sympathetic nerve and the parasympathetic nerve, LF / HF, which is the ratio of the LF component and the HF component, is calculated. Evaluation of nausea: The evaluation of nausea is performed with 0 points for no symptoms and 100 points for the condition leading to vomiting, and the degree of nausea is listened to every 15 minutes from the start of the experiment. Evaluation of motion sickness symptom: The subjective symptom of motion sickness (SSMS) is used to evaluate motion sickness. SSMS consists of 7 items associated with motion sickness: discomfort, heavy head, heat, sweating, drowsiness (drowsiness), hypersalivation, and nausea. Depending on the degree of each symptom, a 4-6 grade is given, with a maximum of 49 points. Listen to this SSMS every 3 minutes for 15 minutes, which corresponds to VR load, and check the transition of symptoms over time. | — |
Countries
Japan
Contacts
Public ContactDaiyu Shinohara
Teikyo Heisei University Department of Acupuncture and Moxibustion, Graduate School of Health Sciences
Outcome results
None listed