Effects of adding esaxerenone to calcium channel blocker in patients with essential hypertension.

Effects of adding esaxerenone to calcium channel blocker in patients with essential hypertension. - Effects of adding esaxerenone to calcium channel blocker in patients with essential hypertension.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000037721

Enrollment

100

Registered

2019-08-19

Start date

2024-05-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

essential hypertension

Interventions

esaxerenone 24 weeks losartan potassium 24 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with essential hypertension. Patients who have been taking calcium channel blocker for more than 8 weeks but still have poor blood pressure control.

Exclusion criteria

Exclusion criteria: Patients taking antihypertensive drugs other than calcium channel blocker during the last 8 weeks. Patients with systolic blood pressure>=160 mmHg and/or diastolic blood pressure>=100 mmHg. Patients with severe renal dysfunction (eGFR <30 mL/min/1.73 m2). Patients with unstable angina. Patients with a history of myocardial infarction or stroke within 24 weeks. Patients with severe liver dysfunction. Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
Changes in blood pressure, pulse rate, serum levels of potassium and creatinine, and eGFR	—

Countries

Japan

Contacts

Public ContactNobukazu Sasaki

Tokyo Women's Medical University Department of Endocrinology and Hypertension

sasaki.nobukazu@twmu.ac.jp03-3353-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026