azoospermia
Conditions
Interventions
We perform in vitro culture of human testicular tissue up to 75 days.
Sponsors
International University of Health and Welfare School of Medicine Department of Obstetrics and Gynecology
Sanno Hospital, St. Mother Obstetrics and gynecology clinic
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Azoospermia 2. Severe oligospermia Above 1 or 2 patients who receive testicular sperm extraction (TESE) treatment.
Exclusion criteria
Exclusion criteria: 1. Patients who can not obtain agreement to participate this study. 2. Patients who judged to be inappropriate for this study by attending doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We perform different methods of in vitro culture of human testicular tissue up to 75 days. After culture, we examine the formation of sperm by histological and molecular analyses. | — |
Secondary
| Measure | Time frame |
|---|---|
| We evaluate the normality of different developmental stages of germ line cells by morphological and molecular analyses. Also, we explore the causes of spermatogenesis dysfunction using molecular approaches. | — |
Countries
Japan
Contacts
Public ContactKazhuhiro Kawamura
International University Health and Welfare School of Medicine Department of Obstetrics and Gynecology
Outcome results
None listed