Glaucoma
Conditions
Interventions
None listed
Sponsors
Tohoku University Hospital
Division of Drug Development and Regulatory Science, Faculty of Pharmacy, Keio University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients over 20 years old at the time of informed consent (2) Consent forms for entry into the registry were available (3) Patients with glaucoma of the following types at enrollment (some patients were diagnosed before screening): / Primary open angle glaucoma (POAG): Characteristic morphological features of the optic disc and retinal nerve fiber layer, without other disease or congenital anomaly; and intraocular pressure > 20 mm Hg / Normal tension glaucoma (NTG): Characteristic morphological features of the optic nerve head and retinal nerve fiber layer, without other disease or congenital anomaly, and intraocular pressure < 20 mmHg / Preperimetric glaucoma (PPG): An ophthalmologic examination revealed abnormalities that suggested glaucoma, such as a glaucomatous optic nerve head or retinal nerve fiber layer defects, but no visual field defects were found in a visual field examination / Pseudo-exfoliation glaucoma (PEG): secondary glaucoma caused by pseudo-exfoliation syndrome
Exclusion criteria
Exclusion criteria: (1) History of treatment with unapproved or off-label uses of drugs in clinical trials (corporate clinical trials, physician-led clinical trials, or extended clinical trials), advanced medical treatments, or other clinical research (2) Presence of serious systemic disease (such as cardiovascular disorder, liver disorder, renal disorder, or endocrine disease), with a judgement by the attending physician that participation in this study was inappropriate (3) Judgement by the research director or assigned doctors that inclusion was inappropriate for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression of visual field loss (MD slope) | — |
Secondary
| Measure | Time frame |
|---|---|
| Vision (highest corrected vision) Intraocular pressure height, weight Pulse rate, blood pressure (systolic and diastolic blood pressure) Fundus examination Stereo fundus examination (optical nerve head parameter) Visual field (MD value, upper half visual field TD value, lower half visual field TD value, foveal threshold, MD slope) Laser speckle fundus blood flow meter (optical nerve head tissue blood flow) Optical coherence tomography (cpRNFLT, mRNFL, mIPL + GCL, mGCC) Refraction test (refractive value) Measurement of corneal thickness, axial length, anterior chamber depth (measurement of central corneal thickness, axial length and anterior chamber depth) QOL Survey (VFQ-25) Oxidative stress marker (dROM), antioxidant value (BAP), AGE | — |
Countries
Japan
Contacts
Public ContactSatoru Tsuda
Tohoku University Hospital Department of Ophthalmology
Outcome results
None listed