diffuse large B cell lymphoma
Conditions
Interventions
RT will be administered daily, 5 days/week. Patients will be treated with 1.5-2 Gy fractions to a total dose of 19.5-20 Gy. Daily image guidance recommended but not mandated.
Sponsors
Department of Radiology, Juntendo University Hospital, Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 20 years of age or older Histologic documentation of stage 1-4 diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS), as defined by the 2016 WHO classification. This would include all entities within this category including germinal center B-cell and non-germinal center B cell type. Further, double hit, triple hit, double expressor, and triple expressor phenotypes are eligible. Completion of at least 3 cycles of a rituximab-containing, anthracycline-based combination chemotherapy regimen (R-CHOP preferred but not mandated). Negative post chemotherapy PET-Scan ANC more than 1000 and platelet count more than 40,000 Negative pregnancy test in women of child-bearing potential within 24 hours of initiating RT. Signed study-specific informed consent
Exclusion criteria
Exclusion criteria: Primary central nervous system lymphoma, primary cutaneous DLBCL, leg type, T-cell/histiocyte-rich large B-cell lymphoma, primary mediastinal (thymic) large B-cell lymphoma, or other distinct non-Hodgkin lymphomas arising from large B-cells included in the WHO classification Any absolute contraindications to irradiation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine if high rates of local control can be maintained after a reduction in the RT dose (from 30 Gy to 20 Gy) after 3 to 6 cycles of chemo-immunotherapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine disease-free survival and overall survival after chemotherapy and low-dose (20 Gy) consolidation radiation therapy. To identify patterns of failure after combined modality therapy using lower doses of consolidation RT | — |
Countries
Japan
Contacts
Public ContactNaoto Shikama
Juntendo University Hospital Department of Radiology
Outcome results
None listed