Study on influence on intraoral sense (taste and the sense of touch) of the laughing gas for healthy adults

Study on influence on intraoral sense (taste and the sense of touch) of nitrous oxide for healthy adults - Influence on intraoral sense of nitrous oxide

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000037462

Enrollment

100

Registered

2019-08-01

Start date

2019-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental phobia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The person that I performed written informed consent by the adult volunteer including the student of Kyushu Dental College, and consent was provided.

Exclusion criteria

Exclusion criteria: The person who corresponds to a taboo of the laughing gas. Or the person that a case and the agreement that had difficulty in understanding of study contents were not provided.

Design outcomes

Primary

Measure	Time frame
I obtain its consent with predetermined written consent at the time of a study cooperation request. I let a target person obtained its consent reply a young man, an adult sense profile and a questionnaire. Under 0% of laughing gas (nitrous oxide), 20%, 30%, 50%, 70%, I carry out following experiments. 1.Blood pressure, the pulse, temperature, ventilatory frequency, the measurement of the percutaneous arterial blood oxygen saturation 2.Judgment (Ramsay score) of the sedation degree by the sedation score 3.The measurement (a mental stress activates excitement of the sympathetic system, and amylase activity increases as an internal self-defense reaction.) of saliva amylase 4.Examination of electric pulpal stimulation (A-delta fiber of four or five maxillary pulps, the threshold measurement by the C fiber stimulation) 5.The measurement of the surface of a body ache by the perception meter (10-20 g) and the oral pain 6.Examination of taste with the electric taste meter 7.Examination of taste with the reagent for examinations for taste qualitative fixed-quantity of the filter paper disk (sweetness, saltiness, acidity, bitterness) 8.Examination for R-R distance (examination of heart rate change)	—

Measure

Time frame

I obtain its consent with predetermined written consent at the time of a study cooperation request. I let a target person obtained its consent reply a young man, an adult sense profile and a questionnaire. Under 0% of laughing gas (nitrous oxide), 20%, 30%, 50%, 70%, I carry out following experiments. 1.Blood pressure, the pulse, temperature, ventilatory frequency, the measurement of the percutaneous arterial blood oxygen saturation 2.Judgment (Ramsay score) of the sedation degree by the sedation score 3.The measurement (a mental stress activates excitement of the sympathetic system, and amylase activity increases as an internal self-defense reaction.) of saliva amylase 4.Examination of electric pulpal stimulation (A-delta fiber of four or five maxillary pulps, the threshold measurement by the C fiber stimulation) 5.The measurement of the surface of a body ache by the perception meter (10-20 g) and the oral pain 6.Examination of taste with the electric taste meter 7.Examination of taste with the reagent for examinations for taste qualitative fixed-quantity of the filter paper disk (sweetness, saltiness, acidity, bitterness) 8.Examination for R-R distance (examination of heart rate change)

—

Countries

Japan

Contacts

Public ContactNozomu Harano

Kyushu Dental University Dental Anesthesiology

harano@kyu-dent.ac.jp093-581-1131

Outcome results