Healthy subjects
Conditions
Interventions
Low gamma-PGA natto
High gamma-PGA natto
Sponsors
Clinical and translatnal methodology, Fuculty of Medicine, University of Tsukuba
1. Takanofoods Co., Ltd. 2. Industrial technology innovation center of Ibaraki prefecture. 3. National agriculture and food research organization, food research institute.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: [At the primary registration] 1. Men and postmenopausal women aged 20-70 years old. 2. BMI not less than 18.5 kg/m2, under 25.0 kg/m2. 3. FPG less than 126 mg/dL and HbA1c less than 6.5%. 4. Subjects who can maintain an everyday lifestyle during study period constantly 5. Capable of giving informed consent. [At the secondary registration] Subjects who meet the following conditions after the meal loading test with 150g of white rice, that performed after primary registration. 1. The levels of casual plasma glucose less than 200 mg/dL. 2. Priority is given to those with a plasma glucose levels more than 140 mg/dL at post-30 min or at any point of time.
Exclusion criteria
Exclusion criteria: [At the primary registration] 1. Subjects who are treated for diabetes. 2. Subjects who are taking medications for dislipidemia hypertention, and anemia. 3. Subjects who are taking warfarin. 4. Subjects who are habitually taking medication and/or supplement (including "food for specified health use", and "foods with function claims") that affect glucose metabolism. 5.Subjects who are diagnosed for anemia or have treatment history for anemia. 6. Subjects who are difficult to collect blood in health checkup and so on oftenly. 7. Subjects who are enrollment in another interventional study. 8. Subjects who have suspected food allergy to test meal 9. Subjects who were recognized unsuitable for this study by the Investigator. [At the secondary registration] 1. Subjects who are confirmed to be difficult to collect blood during continuous blood collection using indwelling needle 2. Subjects who were recognized unsuitable for this study by the Investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incremental area under the curve of plasma glucose (0-30 min) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Incremental area under the curve of plasma glucose (0-15, 0-45, 0-60, 0-90, 0-120 min) 2.The level and change from baselaine of plasma glucose (0-15, 0-30, 0-45, 0-60, 0-90, 0-120 min) 3.The level and change from baseline of plasma insulin (0-15, 0-30, 0-45, 0-60, 0-90, 0-120 min) 4.Organoleptic evaluation (eating quality of test meal) | — |
Countries
Japan
Contacts
Public ContactKoichi Hashimoto
University of Tsukuba, Faculty of Medicene Clinical and translatnal methodology
Outcome results
None listed