Investigation on exhaled nitrogen chemicals in patients undergoing abdominal surgery

Investigation on exhaled nitrogen chemicals in patients undergoing abdominal surgery - Investigation on exhaled nitrogen chemicals in patients undergoing abdominal surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000037442

Enrollment

Registered

2019-07-22

Start date

2019-07-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

abdominal surgery

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patients over 40 years at the time of obtaining informed consent 2) of regular operation patients who undergo abdominal surgery under general anesthesia, those who are scheduled to be treated in the postoperative intensive care unit (ICU) 3) patients who have 3 hours or more of scheduled operation time 4) patients who have obtained consent from the person

Exclusion criteria

Exclusion criteria: 1) patients undergoing surgery requiring general anesthesia within 3 months prior to obtaining informed consent 2) patients with acute respiratory failure (pneumonia, acute respiratory distress syndrome etc.) 3) patients who undergo emergency surgery 4) patients with sepsis or septic shock 5) Patients with progressive neuromuscular disease 6) Patients undergoing thoracic surgery 7) highly obese patients (BMI 35 kg / m2 or more) 8) women who are pregnant or have pregnancy possibility 9) patients who received study drugs or investigational drugs within 3 months prior to obtaining informed consent 10) patinets whom research investigator has determined to be inappropriate

Design outcomes

Primary

Measure	Time frame
change in exhaled NO, NO2, HONO concentration during perioperative period	—

Secondary

Measure	Time frame
1) relevance of exhaled NO, NO2, HONO and blood ROS during perioperative period 2) relevance of exhaled NO, NO2, HONO and blood cytokines during perioperative period 3) relevance of exhaled NO, NO2, HONO and blood biomarkers during perioperative period 4) relevance of exhaled NO, NO2, HONO and hematological examination, blood biochemical examination, arterial blood gas analysis examination during perioperative period 5) relevance of exhaled NO, NO2, HONO and pulmonary function during perioperative period 6) Whether the exhaled NO, NO2 and HONO concentrations are related to the anesthesia method during perioperative period 7) Whether the exhaled NO, NO 2 and HONO concentrations in the perioperative period are related to the operation conten	—

Measure

Time frame

1) relevance of exhaled NO, NO2, HONO and blood ROS during perioperative period 2) relevance of exhaled NO, NO2, HONO and blood cytokines during perioperative period 3) relevance of exhaled NO, NO2, HONO and blood biomarkers during perioperative period 4) relevance of exhaled NO, NO2, HONO and hematological examination, blood biochemical examination, arterial blood gas analysis examination during perioperative period 5) relevance of exhaled NO, NO2, HONO and pulmonary function during perioperative period 6) Whether the exhaled NO, NO2 and HONO concentrations are related to the anesthesia method during perioperative period 7) Whether the exhaled NO, NO 2 and HONO concentrations in the perioperative period are related to the operation conten

—

Countries

Japan

Contacts

Public ContactKazumi Funaki

Tottori University Division of Anesthesiology and Critical Care Medicine

funapon1116@gmail.com0859-38-6657

Outcome results