Pathophysiology of dementia on synaptic density and tau deposition in the brain

Synaptic density and tau deposition in dementia - Synaptic density and tau deposition in dementia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000037410

Enrollment

Registered

2019-07-18

Start date

2019-07-19

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The purpose of this study is to evaluate levels of different tau proteins using [18F]PM-PBB3 and [11C]PBB3 along with changes in synaptic density in patients with dementia and healthy subjects.

Interventions

Intravenous injection of PET tracers

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy participants aged 20 to 85 years or below 1.Individuals who have no history of psychiatric disease 2.Individuals who are consent to participate in this study Patients Met with criteria for AD, DLB and FTLD

Exclusion criteria

Exclusion criteria: 1.Individuals who are nursing, pregnant and have a chance of pregnancy. 2.Individuals who have claustrophobia. 3.Individuals with illness that affects the study 4.Individuals who are assessed unsuitable for participants by doctors in charge.

Design outcomes

Primary

Measure	Time frame
Difference in [18F]PM-PBB3 binding, and [11C]PBB3 binding. Changes in [11C]UCB-J	—

Secondary

Measure	Time frame
Correlations between [11C]UCB-J and tau deposition	—

Countries

Japan

Contacts

Public ContactYasuomi Ouchi

Hamamatsu University School of Medicine Department of Biofunctional Imaging

ouchi@hama-med.ac.jp053-435-2466

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026