Retrospective observational study of mismatch repair protein immunohistochemistry and microsatellite instability test for Lynch syndrome screening test

Retrospective observational study of mismatch repair protein immunohistochemistry and microsatellite instability test for Lynch syndrome screening test - Retrospective observational study of Lynch syndrome screening tests

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000037382

Enrollment

2200

Registered

2019-09-01

Start date

2019-07-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lynch syndrome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Included cases were investigated by Lynch syndrome screening test between May 1 of 2005 and March 31 of 2019. Results of MMR immunohistochemistry and MSI tests were adequately archived in the medical records.

Exclusion criteria

Exclusion criteria: Analysis of MMR immunohistochemistry and/or MSI tests were inadequate, or the imformation of those tests were not sufficiently archived in the medical records.

Design outcomes

Primary

Measure	Time frame
Concordance of MMR immunohistochemistry and MSI test.	—

Secondary

Measure	Time frame
(1) Relationship between the germline mutation status and MMR/MSI tests. (2) Analysis of disconcordance case between MMR and MSI tests.	—

Countries

Japan

Contacts

Public ContactHiroshi Kawachi

The Cancer Institute Hospital of Japanese Foundation for Cancer Research Department of Pathology

hiroshi.kawachi@jfcr.or.jp03-3520-0111

Outcome results