Examination of the effect of gum chewing training on a questionnaire survey and saliva profiles

Examination of the effect of gum chewing training on a questionnaire survey and saliva profiles - Examination of the effect by gum chewing training

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000037338

Enrollment

450

Registered

2019-07-31

Start date

2015-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Intervention : 4times daily for 6 weeks chewing 2 tablets of xylitol gum (lime mint taste: 1.5 g / piece) 10min Control : Do not chew gum

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Among the employees of Isetan Mitsukoshi Ltd. those who gave written consent after fully understanding the purpose and content of this study

Exclusion criteria

Exclusion criteria: 1) Under medication 2) Regularly consume medicines, food for specified health use, health food, etc. that may affect the test results 3) Patient or had a history of serious diseases such as heart, liver, kidney, digestive system etc. 4) Pregnant (including those who may be) , who wish pregnant during the study period or who are lactating 5) Heavy drinkers 6) Have irregular diets, irregular shift rhythms, shift workers, late-night workers, etc. 7) Allergic to medicines and food 8) Skin allergy such as atopy 9) Smoke more than 21 per day on average 10) Participating in clinical trials of other medicines or health food, within 4 weeks after the trial, or who are planning to participate in other clinical trials after consenting to participate in this trial 11) Have performed special facial care (facial face, esthetic, peeling, laser treatment, etc.) 12) Trial investigator judged as inappropriate to participate in this study

Design outcomes

Primary

Measure	Time frame
Questionnaire of subjective evaluation 1) Stress (HAD scale) 2) Stress (short BJSQ)	—

Secondary

Measure	Time frame
Saliva test 1) Secretion volume 2) pH 3) Buffering ability 4) Stress indicator substances (cortisol, alpha-amylase, S-IgA, Substance P) Bad breath (total amount of sulfide in breath) Skin examination 1) Number and size of skin texture, wrinkles and pores 2) Moisture content and elasticity of skin	—

Countries

Japan

Contacts

Public ContactMie Kaneko

Tsurumi University School of Dental Medicine Department of Pathology

kaneko-m@tsurumi-u.ac.jp045-580-8362

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026