Normal healthy volunteers
Conditions
Interventions
PET/CT after protein supplementation
PET/CT after water-intake
Sponsors
National Institute of Radiological Sciences (NIRS), QST
Meiji Co., Ltd.
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy volunteers 1.Subjects with ability to make informed consent 2. Adult male who is from 20 years of age to 40 years old at the time of obtaining consent. 3. Adult male whose BMI is equal to or more than 18.5 kg/m2, and less than 25.0 kg/m2 at the time of study.
Exclusion criteria
Exclusion criteria: 1.Subjects took agents (H2 blocker, PPI, digestive enzyme medicine), an unregulated drug (stomachic, digestant) which might have an influence on this study on the day of the study 2.Subjects with serious traumatic disorder or locomotor injury/ disease in the femoral region 3.Subjects with severe or chronic physical complications/disorders 4.Subjects who is considered to have diabetes, liver dysfunction, renal dysfunction, severe anemia, polycythemia, or diseases including infection, collagen disease, rheumatic fever, myocardial infarction, liver cirrhosis, sepsis, malignancy, viral disease, acute hepatitis, encephalitis, and endocrine disease by doctors with responsibilities in this study 5.Subjects with a milk allergy or lactose intolerance 6.Subjects with smoking habituation 7.Subjects who continue mild to intensive exercise habituation (i.e. 30 minutes a day, twice a week more than one year) 8.Subjects with claustrophobia 9.Subjects who participated in any other clinical trials for one month before this study 10.From the standpoint of radiation exposure from a nuclear medicine scan, subjects who received radiological examination such as X-rays, CT, PET, DEXA as clinical practice other than medical check-up in 12 months, or who have participated in other nuclear medicine scans as healthy volunteers in 6 months prior to the start of this study 11. Subjects who are considered to be inappropriate for participation by doctors with responsibilities in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-11 Methionine Influx rate constant Ki from plasma into skeletal muscle protein determined by graphical plotting analysis of C-11 methionine PET/CT imaging | — |
Countries
Japan
Contacts
Public ContactKazuko Suzuki
National Institute of Radiological Sciences (NIRS), QST Clinical Reseach Support Section
Outcome results
None listed