Rumination Focused Cognitive-Behavioral Therapy for Treatment-resistant Depression: A Pilot study

Rumination Focused Cognitive-Behavioral Therapy for Treatment-resistant Depression: A Pilot study - Rumination Focused Cognitive-Behavioral Therapy for Treatment-resistant Depression: A Pilot study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000037191

Enrollment

Registered

2019-06-27

Start date

2019-07-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment-resistant Depression

Interventions

Rumination Focused Cognitive-Behavioral Therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) having a diagnosis of DSM-IV Major Depressive Disorder confirmed with the SCID 2) have been treated with antidepressants or cognitive behavioral therapy for depression at least 8 weeks up to screening. 3) GRID-HAMD-17>=14 4) can attend session more than 8 5) 20 years old <= age <70 years old 6) can obtain written consent

Exclusion criteria

Exclusion criteria: 1) No alcohol or substance use disorder in 12 months prior to the screening 2) No history or concurrent manic episode or psychotic disorders 3) No other primary DSM-IV Axis I Disorders at screening 4) No comorbid of antisocial personality disorder 5) No serious suicidal ideation at screening 6) No organic brain lesions or major cognitive deficits in a year prior to the screening 7) No severe or unstable medical co-morbidities at screening 8) No structured psychotherapy during the intervention. 9) Other relevant reason decided by the CBT principal investigator.

Design outcomes

Primary

Measure	Time frame
1. Baseline reduction score of GRID-Hamilton Depression Rating Scale (GRID-HAMD) at 16wk 2. Drop-out rate	—

Secondary

Measure	Time frame
1. Baseline reduction score of GRID-Hamilton Depression Rating Scale (GRID-HAMD) at 28 and 40wk 2. Beck Depression Inventory (BDI-II), Generalized Anxiety Disorder (GAD-7), Ruminative Responses Scale (RRS), Sheehan Disability Scale (SDISS), Cognitive-Behavioral Avoidance Scale (CBAS), Coping Inventory for Stressful Situations (CISS): 0,8,16,28,40 wks 3. Quick Inventory of Depressive Symptomatology (QIDS), Euro-Qol (EQ-5D), Session Rating Scale (SRS) at each session 4. Client satisfaction questionnaire (CSQ-8j): 0, 8,16 wks	—

Measure

Time frame

1. Baseline reduction score of GRID-Hamilton Depression Rating Scale (GRID-HAMD) at 28 and 40wk 2. Beck Depression Inventory (BDI-II), Generalized Anxiety Disorder (GAD-7), Ruminative Responses Scale (RRS), Sheehan Disability Scale (SDISS), Cognitive-Behavioral Avoidance Scale (CBAS), Coping Inventory for Stressful Situations (CISS): 0,8,16,28,40 wks 3. Quick Inventory of Depressive Symptomatology (QIDS), Euro-Qol (EQ-5D), Session Rating Scale (SRS) at each session 4. Client satisfaction questionnaire (CSQ-8j): 0, 8,16 wks

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Countries

Japan

Contacts

Public ContactAtsuo Nakagawa, MD, PhD

Keio University School of Medicine Department of Neuropsychiatry

anakagawa@keio.jp03-5363-3235

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026