Detecting low allele frequency of compound minor mutation using high-sensitivity next generation sequencer for EGFR mutant lung cancer

Detecting low allele frequency of compound minor mutation using high-sensitivity next generation sequencer for EGFR mutant lung cancer - Detecting compound minor mutation using NGS for EGFR mutant lung cancer

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000037133

Enrollment

Registered

2019-06-21

Start date

2019-06-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

EGFR-mutant lung cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) EGFR-mutant lung cancer 2) Written informed consent

Exclusion criteria

Exclusion criteria: Other cases attending physician it is determined unsuitable for registration of the study

Design outcomes

Primary

Measure	Time frame
Detection rate of EGFR compound minor mutation using NGS	—

Secondary

Measure	Time frame
1) Allele frequency of sensitive mutation and compound minor mutation, and its corelation for response rate and PFS. 2) T790M detection rate at diagnostic phase and re-biopsy phase 3) Subsequent allele frequency change of EGFR compound minor mutation	—

Countries

Japan

Contacts

Public ContactKei Morikawa

St. Marianna University School of Medicine Division of Respiratory Diseases, Department of Internal Medicine

mokke5454@yahoo.co.jp044-977-8111

Outcome results