Comparative clinical trial of Eplerenone and Esaxerenone for hypertension with chronic heart failure treating Eplerenone

Comparative clinical trial of Eplerenone and Esaxerenone for hypertension with chronic heart failure treating Eplerenone - Comparative clinical trial of Eplerenone and Esaxerenone for hypertension with chronic heart failure treating Eplerenone

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000037113

Enrollment

150

Registered

2019-06-19

Start date

2019-05-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension with chronic heart failure treating Eplerenone

Interventions

Switch from Eplerenone 50mg/day to Esaxerenone2.5mg/day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hypertension with chronic heart failure treating Eplerenone eGFR>30mL/min/1.73m2 Patients from whom informed consent was obtained

Exclusion criteria

Exclusion criteria: eGFR<29mL/min/1.73m2 Patients from whom informed consent was not obtained

Design outcomes

Primary

Measure	Time frame
Blood pressure	—

Secondary

Measure	Time frame
1) ANP, BNP 2)sCr, eGFR, renin, angiotensin-II, aldosterone, cortisol, Na, K, Cl 3) Urine (albumin, Na, K, Cl, osm)	—

Countries

Japan

Contacts

Public ContactMitsue Akiyama

Sekino Laboratory Department of Research

skn-np@sekino-hospital.com03-3986-5501

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026