The mechanism of onset and development in liver cancer induced by nonalcoholic steatohepatitis (NASH) using human clinical materials -From the view point of autophagy regulator p62 and antioxidative stress factor Nrf2-

The role of autophagy in hepatocellular carcinoma induced by chronic liver diseases - The relationship between hepatocellular carcinoma and autophagy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000037080

Enrollment

150

Registered

2023-12-31

Start date

2019-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma induced by NASH

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hepatocellular carcinoma induced by NASH or chronic hepatitis C, or metastasis from colon cancer

Exclusion criteria

Exclusion criteria: Hepatocellular carcinoma induced by chronic hepatitis B

Design outcomes

Primary

Measure	Time frame
The expression levels of p62 and Nrf2	—

Secondary

Measure	Time frame
the grade of malignancy, over all survival	—

Countries

Japan

Contacts

Public ContactKosuke Okada

University of Tsukuba Hospital Gastroenterology/ Tsukuba Preventive Medicine Research Center

okadakosuke-2000@umin.ac.jp029-853-3525

Outcome results