The effect of SPI (surgical pleth index)-guided analgesia on postoperative immune system in the elderly patients

The effect of SPI (surgical pleth index)-guided analgesia on the peri-operative stress hormone secretion and postoperative immune system in the elderly patients - SPI-SHI

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000036991

Enrollment

Registered

2023-01-01

Start date

2019-05-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

randomized controlled trial

Interventions

Intavenous remifentanil wiill be titrated until surgical pleth index (SPI) value is within 20-50 in SPI group. Time intervalof administration is minimum 5min Intavenous remifentanil will be titrated

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients aged more than 65 years with a physical status of 1-3(the American Society of Anesthesiologists rating) who are scheduled to undergo GI cancer surgery

Exclusion criteria

Exclusion criteria: Patients with a history of hypersensitivity to drugs, and those receiving analgesics, sedatives or psychiatric medication will be excluded.

Design outcomes

Primary

Measure	Time frame
the difference of intravenous IV remifentanil dose	—

Secondary

Measure	Time frame
peri operative cortisol, epinephrine, norepinephrine, ACTH,IL6, TNF a, NK cell activity	—

Countries

Asia(except Japan)

Contacts

Public ContactYoung Ju Won

Guro Hospital, Korea University College of Medicine Department of Anesthesiology and Pain Medicine

moma2@naver.com82-2-2626-2-1437

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026