Lactoferrin supplementation for repeated implantation failure patients with uterine/vaginal dysbiosis

Lactoferrin supplementation for repeated implantation failure patients with uterine/vaginal dysbiosis - Lactoferrin supplementation for repeated implantation failure patients with uterine/vaginal dysbiosis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000036990

Enrollment

100

Registered

2019-06-07

Start date

2019-06-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Repeated implantation failure

Interventions

Oral supplementation of 700mg/day lactoferrin for 28 days or more for infertile patients with a history of repeated implantation failure and collection of circulating blood, endometrial fluid, and vag

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Infertile women requiring artificial reproductive technology

Exclusion criteria

Exclusion criteria: Infertile women lacking anatomical uterus and/or vagina

Design outcomes

Primary

Measure	Time frame
(i) Measurement of lactoferrin concentration in circulating blood, endometrial fluid, and vaginal secretion (ii) Microbiota analysis of endometrial fluid, and vaginal secretion (iii) Reproductive outcome	—

Countries

Japan

Contacts

Public ContactKotaro Kitaya

Reproduction Clinic Osaka IVF Center

kitaya@koto.kpu-m.ac.jp0661363344

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026