Dose-response relationship of polysuilfides enriched garlic intake on fractional exhaled hydrogen sulfide and the physiological responses to high-intensity continous exercise

Dose-response relationship of polysuilfides enriched garlic intake on fractional exhaled hydrogen sulfide and the physiological responses to high-intensity continous exercise - Dose-response relationship of polysuilfides enriched garlic intake on fractional exhaled hydrogen sulfide and the physiological responses to high-intensity continous exercise

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000036987

Enrollment

Registered

2019-06-06

Start date

2019-06-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recreationally Active

Interventions

Sandwich containing polysulfide enriched garlic 2g/4g/6g Placebo sandwich not containing polysulfide enriched garlic

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Healthy adults (2) free from injury (3) Do not have any current or history of cardiovascular, metabolic or pulmonary disease (4) No contraindication for blood sampling procedure (5) Pass The Physical Activity Readiness Questionnaire (PAR-Q)

Exclusion criteria

Exclusion criteria: (1) Smoker (2) Individual who consume any dietary supplements, quasi drugs or medicines within past 4 weeks (3) On medication (4) Receiver of blood transfusion within 1 month prior to screening (5) Receiver of any investigational research agent prior to 30 days of experimental trial and individual who have a history of or current clinically significant disease (6) Clinical population or an individual with heart/vascular related problem (7) Individual with the medical histories of alcoholism or drug dependence (8) Individual who have contraindication with high intensity exercise

Design outcomes

Primary

Measure	Time frame
Pharmacokinetic dose-reponses (plasma hydrogen sulfide) Resting blood pressure (systolic blood pressure, diastolic blood pressure and mean arterial pressure)	—

Secondary

Measure	Time frame
Fractional exhaled hydrogen sulfide Niric oxide level Renal function (Urea, Nitrogen, Creatine) Blood glucose and blood lactate Plasma sodium and potassium Oxygen cost of exercise Oxidant and antioxidant markers Cognitive function	—

Countries

Asia(except Japan)

Contacts

Public ContactAdam Linoby

Universiti Teknologi MARA Faculty of Sports Science and Recreation

linoby@uitm.edu.my+60133632005

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026