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The Effect of Acute and Chronic L-Citrulline Extract Supplementation on Vasodilatory, Nitric Oxide Bioavailability and Exercise Performance in Human Adults

The Effect of Acute and Chronic L-Citrulline Extract Supplementation on Vasodilatory, Nitric Oxide Bioavailability and Exercise Performance in Human Adults - The Effect of Acute and Chronic L-Citrulline Extract Supplementation on Vasodilatory, Nitric Oxide Bioavailability and Exercise Performance in Human Adults

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000036962
Enrollment
8
Registered
2019-06-04
Start date
2019-06-04
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

6 grams per day of L-citrulline Placebo capsule not containing L-citrulline

Sponsors

Faculty of Sports Science and Recreation, Universiti Teknologi MARA
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Healthy recreationally active males 2. Free from injury. 3. Do not have any current or history of cardiovascular, metabolic, or pulmonary disease 4. No contraindication for blood sampling procedure. 5. Pass The Physical Activity Readiness Questionnaire (PAR-Q)

Exclusion criteria

Exclusion criteria: 1. Smoker 2. Individual who consume any dietary supplements, quasi drugs or medicines within past 4 weeks. 3. On medication 4. Receiver of blood transfusion within 1 month prior to screening 5. Receiver of any investigational research agent prior to 30 days of experimental trial and individual who have a history of or current clinically significant disease. 6. Clinical population or an individual with heart/vascular related problem 7. Individual with the medical histories of alcoholism or drug dependence 8. Individual who have contraindication with high intensity exercise

Design outcomes

Primary

MeasureTime frame
1. Resting blood pressure (systolic blood pressure, diastolic blood pressure and mean arterial pressure) 2. Continuous and intermittent endurance exercise performance

Secondary

MeasureTime frame
1. Nitric oxide level 2. Renal function (Urea nitrogen, Creatine) 3. Blood glucose and blood lactate 4. Plasma sodium and potassium 5. Oxygen cost of exercise 6. Oxidant and antioxidant markers 7. Cognitive function

Countries

Asia(except Japan)

Contacts

Public ContactAdam Linoby

Universiti Teknologi MARA Faculty of Sports Science and Recreation

linoby@uitm.edu.my+60133632005

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026