The effect of lactulose on gasses emanating from skin surface. Randomized double-blind, placebo-controlled crossover study.

The effect of lactulose on gasses emanating from skin surface. Randomized double-blind, placebo-controlled crossover study. - The effect of lactulose on gasses emanating from skin surface.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000036803

Enrollment

Registered

2019-05-23

Start date

2019-05-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intake of lactulose 4g/day for 2weeks Intake of placebo for 2weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Healthy subject

Exclusion criteria

Exclusion criteria: 1) Subjects with severe hepatic, renal, heart, gastrointestinal, cerebrovascular, endocrine, metabolic or infection diseases. 2) Subjects with the history of gastrointestinal resection. 3) Subjects with gastrointestinal dysfunction such as irritable bowel syndrome or inflammatory bowel disease. 4) Subjects who use medicines or supplements that may influence feces frequency; e.g. antibiotics, probiotics, laxatives, antidiarrheals, fibers. 5) Subjects with milk allergy. 6) Subjects with lactose intolerance 7) Subjects who participate another study. 8) Subjects who are judged inappropriate for the study by the investigator or the physician.

Design outcomes

Primary

Measure	Time frame
Emission flux of ammonia from skin surface	—

Secondary

Measure	Time frame
Emission flux of gasses except ammonia from skin surface	—

Countries

Japan

Contacts

Public ContactYoshika Sekine

Tokai University Graduate School of Science

sekine@keyaki.cc.u-tokai.ac.jp0463-58-1211

Outcome results