A prospective observational study on the effects and mechanisms of zinc deficiency in patients with ulcerative colitis

A prospective observational study on the effects and mechanisms of zinc deficiency in patients with ulcerative colitis - A prospective observational study on the effects and mechanisms of zinc deficiency in patients with ulcerative colitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000036787

Enrollment

Registered

2019-06-01

Start date

2019-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients older than 12 years of age at the time of consent acquisition. 2. Out- or inatients with ulcerative colitis in our hospital. 3. Treatment history is not matter. 4. The severity, activity and remission periods are not matter. 5. Patients who obtained written consent for the participation of this study

Exclusion criteria

Exclusion criteria: 1. Patients under 12 years old 2. Patient with right-sided ulcerative colitis (as it is difficult to determine by biopsy from the rectum). 3. Patients with difficulty for perfoming colonoscopy and biopsy. 4. In addition, patients whom the doctor in charge judged as inappropriate.

Design outcomes

Primary

Measure	Time frame
Correlation between zinc deficiency and the expressions and activities of ATP-requiring ATP metabolism related enzymes in the intestinal tissue.	—

Secondary

Measure	Time frame
1. Correlation between zinc deficiency or the expressions and activities of zinc-requiring ATP metabolism related enzyme in the intestinal tissue, and clinical symptoms of the enzyme, blood test findings, diesase severity (CAI, endoscopic severity), prognosis (active phase: improvement rate, remission rate, mucosal healing rate, cumulative surgery rate, remission period rate, relapse rate). 2.Correlation between expressions and activities of zinc-requiring ATP metabolism related enzymes and expressions of inflammation related mediators. 3. Correlation between enhancers of zinc absorption and expressions of inflammatory mediators.	—

Measure

Time frame

1. Correlation between zinc deficiency or the expressions and activities of zinc-requiring ATP metabolism related enzyme in the intestinal tissue, and clinical symptoms of the enzyme, blood test findings, diesase severity (CAI, endoscopic severity), prognosis (active phase: improvement rate, remission rate, mucosal healing rate, cumulative surgery rate, remission period rate, relapse rate). 2.Correlation between expressions and activities of zinc-requiring ATP metabolism related enzymes and expressions of inflammation related mediators. 3. Correlation between enhancers of zinc absorption and expressions of inflammatory mediators.

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Countries

Japan

Contacts

Public ContactYuki Murakami

Asahikawa Medical University Department of Medicine, Division of Gastroenterology and Hematology/Oncology

yuuki1228@asahikawa-med.ac.jp0166-68-2462

Outcome results