Healthy adults
Conditions
Interventions
Sponsors
RIKEN
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Individual who has received sufficient explanation about purpose and content of research, and consenting ability, and who volunteers with his/her free intent and gives written informed consent.
Exclusion criteria
Exclusion criteria: (1) Individual who has been taken medications, quasi-drugs (excluding topical drugs) and supplements for more than 5 days a week within a month before screening test, or who plans to take those for more than 5 days a week during research period. (2) Individual who has a serious disease such as cranial nerve disease, liver disease, kidney disease, heart disease, cardiovascular disease, malignancy, or who has history of that. (3) Individual who has nervous seizure (such as Loss of consciousness, coma, convulsions), color blindness, diabetes, or arrhythmia, or who has history of that. (4) Individual who has dysfunction of autonomic nervous system (whose value of LF/HF is more than 10 on the screening test). (5) Individual who has food allergy (6) Individual who can not intake bitter chocolate (dark chocolate) (*1) (7) Individual who consume excessive alcohol (average of 60 g/day or more in alcohol equivalent) (8) Individual who has a smoking habit (9) Individual who have day and night shift work and night work (10) Individual has poor performance, less than 50% correct answer rate) in the cognitive function task (confirmation of answer ability) at the screening test. (11) Individual who has participated in other clinical research within a month before the research, or plan to participate that during the study period. (12) Individual who is pregnant, possibly pregnant, or breastfeeding, or who has plan or wish for pregnancy during the study period. (13) Individual whom principal investigator or sub-investigator judged to be inappropriate as a subject. *1. Bitter (or dark) chocolate refers to chocolate with 40-60 % cacao mass containing no milk (or milk component), chocolate with low sugar or milk content and high bitterness, and chocolate with 70-90% cacao content and low sugar.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of cognitive task performance at the period from 5 to 15 minutes after test food ingestion and from 30 to 45 minutes after test food ingestion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of subjective feelings, measured by visual analog scale, before and after test food ingestion. Comparison of autonomic nervous function before and after test food ingestion. Number of side effect in 24 hours after test food ingestion. | — |
Countries
Japan
Contacts
Public ContactAkihiro Sasaki
RIKEN Center for Biosystems Dynamics Research Laboratory for Pathophysiological and Health Science
Outcome results
None listed