Prospective and exploratory study for disease specific biomarkers and objective indicators in neurodegenerative diseases

Prospective and exploratory study for disease specific biomarkers and objective indicators in neurodegenerative diseases - Prospective study for biomarkers in neurodegenerative diseases

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000036570

Enrollment

600

Registered

2019-04-22

Start date

2014-05-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

All Neurodegenerative diseases specifically Parkinson&#39

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients over 18 years old with parkinsonism, who provided (by own or by a representative) a written informed consent. Parkinsonism is defined as two or more symptoms in tremor, akinesia, muscular rigidity, and postural reflex disorder, which show a slow progressive course. As a disease control, this study also targets at patients who receive spinal fluid drainage to prevent spinal cord ischemia among thoracoabdominal surgery.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Assessment of parkinsonism (MDS-UPDRS score, Hoehn-Yahr stage)	—

Secondary

Measure	Time frame
Cognitive evaluation (MMSE, Visual Perspective test, etc.), Brain imaging evaluation (structural MRI , functional MRI, etc.) and biochemical markers of cerebrospinal fluid and serum (catecholamine concentration, alpha-synuclein concentration, cerebrospinal fluid amyloid aggregation, etc.)	—

Countries

Japan

Contacts

Public ContactKotaro Ogawa

Osaka University Graduate School of Medicine Neurology

crgou@neurol.med.osaka-u.ac.jp+(81)-6-6879-3571

Outcome results