Patients who undergo pancreatoduodenectomy for peri-pancreatic tumors such as pancreatic cancers or lower bile duct cancers
Conditions
Interventions
Patients who will undergo PD will be prospectively registered and assigned to K-2S plus group from patients who have started registration. When the number of cases in the K-2S plus group reaches 20, t
Sponsors
Kumamoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Cases where the age of registration date is over 20 years old (2) PS (ECOG) 0 or 1 case (3) Cases that meet all the following conditions For all test items, the latest value is used within 14 days before surgery (a test on the same day two weeks before the registration date is acceptable). 1) White blood cells> or more 4,000 and < or less 12,000. 2) Neutrophil> or more 2,000. 3) Platelets> or more 100,000. 4) Hemoglobin> or more 8.0. 5) AST< or less 100. 6) ALT< or less 100. 7) Total bilirubin< or less 1.2. 8) Serum creatinine< or less 1.2. (4) Cases that can be taken orally (Dysphagia score< or less 1).
Exclusion criteria
Exclusion criteria: (1) Patients who are contraindicated with K-2S plus or Erental 1) A case with allergies to eggs, dairy products and soy 2) A case with hypersensitivity to K-2S plus 3) A case with hypersensitivity to Ellenthal 4) A case with amino acid metabolism disorder (2) Cases with active bacterial and fungal infections (cases with fever above 38 degree and cases where bacterial infection has been shown by imaging or bacteriological examination). (3) A case that is complicated by psychosis or psychiatric symptoms and difficult to participate in this study. (4) Cases that the study responsible (share) physician judged inappropriate for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Defecation frequency Fecal condition (Bristol scale) | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight loss rate Lymphocyte count and reduction rate Serum albumin level and reduction rate Serum prealbumin (transthyretin) levels and reduction rates Postoperative complication rate (Clavian-Dindo IIIa or more) Enteral nutrition protocol completion rate Enteral nutrition protocol total administered calories Total calories required after enteral feeding protocol | — |
Countries
Japan
Contacts
Public ContactYo-ichi Yamashita
Graduate School of Medical Sciences, Kumamoto University Department of Gastroenterological Surgery
Outcome results
None listed