Patient Undergoing Elective Surgery under General Anesthesia
Conditions
Interventions
Propofol will be administered using target-controlled infusion. The target concentration is controlled between 3 to 6 mcg/ml during the induction of anesthesia, and 2 to 5 mcg/ml during maintenance of
Sponsors
Showa University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient undergoing elective surgery under general anesthesia (20 patients aged 20 to 64, and 20 patients aged 65 or older)
Exclusion criteria
Exclusion criteria: (1) Contraindication to propofol or hydroxyethil starch administration (2) Obstructive and/or restrictive ventilatory impairment (3) American Society of Anesthesiologists physical status 4 or larger
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of exhaled propofol cocentration versus plasma propofol concentration or an index simialr to the ratio during the general anesthesia | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ratio of measured propofol cocentration versus predicted plasma propofol concentration or an index simialr to the ratio during the general anesthesia 2. pharmacokinetic model to predict plasmaconcentration using exhaled propofol concentration | — |
Countries
Japan
Contacts
Public ContactKenichi Masui
Showa University School of Medicine Department of Anesthesiology
Outcome results
None listed