Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress pollinosis

Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress pollinosis - Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in Japanese cypress pollinosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000036402

Enrollment

120

Registered

2019-04-04

Start date

2018-03-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

combined Japanese cedar and Japanese cypress pollinosis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: This prospective study included healthy controls, patients with combined JC and Japanese cypress pollinosis who were not treated with SLIT, and patients with combined pollinosis treated with SLIT.

Exclusion criteria

Exclusion criteria: The exclusion criteria were the presence or history of asthma or asthma-like symptoms.

Design outcomes

Primary

Measure	Time frame
Peripheral blood mononuclear cells (PBMCs) from patients with JC and Japanese cypress pollinosis who received SLIT with standardized JC pollen extract which was administered over a period of 1 to 2 years, were incubated with Cry j 1, Cha o 1 and Cha o 3 antigens. Antigen-induced production of IL-5, IL-10, IL-17 and IFN-g.	—

Secondary

Measure	Time frame
Serum concentrations of antigen-specific IgE and IgG4 were measured. A basophil activation test was also performed.	—

Countries

Japan

Contacts

Public ContactHirotaka Kikuoka

Shiga University of Medical Science Department of Otorhinolaryngology

kikuoka@belle.shiga-med.ac.jp0775482111

Outcome results