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Randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the effect of nicotinamide mononucleotide (NMN) on the body composition in elderly persons

Randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the effect of nicotinamide mononucleotide (NMN) on the body composition in elderly persons - The study to evaluate the effect of nicotinamide mononucleotide (NMN) on the body composition in elderly persons

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000036321
Enrollment
42
Registered
2019-06-01
Start date
2019-06-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy subjects

Interventions

Subjects receive 250 mg/day of NMN for 12 weeks. Subjects receive placebo for 12 weeks.

Sponsors

Department of Diabetes and Metabolic Diseases, The University of Tokyo Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1)the healthy subjects who agree to the study. 2)Body Mass Index 22-28 3)no smoking history

Exclusion criteria

Exclusion criteria: 1)The subjects who take functional food that may affect the trial 2)The subjects who take more than one hour daily exercise for more than 6 months 3)The subjects with the history of serious disease (malignant neoplasms, cardiac failure and myocardial infarction ) 4)The subjects with chronic disease 5)The subjects who take medicines 6)The subjects with allergic disorders. 7)The subjects who participate in any clinical trial within 90 days of the commencement of the trial 8)The subjects judged as ineligible by clinical investigators

Design outcomes

Primary

MeasureTime frame
To evaluate the skeletal muscle index by the bioelectrical impedance analysis

Secondary

MeasureTime frame
1) To evaluate the parameters related to glucose metabolism 2)To evaluate the vascular endothelial function by FMD

Countries

Japan

Contacts

Public ContactMasaki Igarashi

The University of Tokyo Hospital Department of Diabetes and Metabolic Diseases

igarashi-tky@umin.ac.jp03-3815-5411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026