A prospective comparative study on proteins regulating glial activation in cerebrospinal fluid of patients with neurodegenerative diseases.

A prospective comparative study on proteins regulating glial activation in cerebrospinal fluid of patients with neurodegenerative diseases. - A comparative study on proteins regulating glial activation in cerebrospinal fluid of patients with neurodegenerative diseases.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000036299

Enrollment

110

Registered

2019-06-01

Start date

2019-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

amyotrophic lateral sclerosis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. ALS group Patients who is diagnosed ALS in accordance with El Escorial classification. 2. Neurodegenerative diseases group Patients who is diagnosed neurodegenerative diseases with parkinsonism (Parkinson's disease, progressive supra nuclear palsy, corticobasal syndrome, multiple system atrophy). 3. Inflammatory neurological diseases including neuromyelitis optica or multiple sclerosis. 4. Patients who was performed lumbar puncture for diagnosis and the neurological diseases with extensive gliosis were excluded.

Exclusion criteria

Exclusion criteria: Patients with a history of cerebrospinal cavity infection Patients with a history of intrathecal administration Patients with a surgery of spine or spinal cord Patients who were decided to be inappropriate by the researchers

Design outcomes

Primary

Measure	Time frame
The protein levels in cerebrospinal fluid at diagnosis.	—

Countries

Japan

Contacts

Public ContactTomomi Shijo

Tohoku University Hospital Department of Neurology

shijo-t@med.tohoku.ac.jp022-717-7189

Outcome results