Comprehensive study to improve long-term prognosis of patients with idiopathic normal pressure hydrocephalus

Comprehensive study to improve long-term prognosis of patients with idiopathic normal pressure hydrocephalus - Study to improve long-term prognosis of iNPH patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000036290

Enrollment

100

Registered

2019-04-01

Start date

2019-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

idiopathic normal pressure hydrocephalus healthy adult volunteer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) the age of onset of iNPH is defined as 60 years or older 2) More than one of the clinical triad: gait disturbance, cognitive impairment, and urinary incontinence on the iNPH grading scale (iNPHGS) 3) both ventriculomegaly of Evans' index>0.3 and tight high-convexity and medial subarachnoid spaces on MRI 4) Above-mentioned clinical symptoms cannot be completely explained by other neurological or non-neurological diseases

Exclusion criteria

Exclusion criteria: 1) no reliable family 2) no informed consent from the patients and their family about CSF Tap test and shunt surgery

Design outcomes

Primary

Measure	Time frame
modified Rankin scale(mRS)5 years after shunt surgery	—

Secondary

Measure	Time frame
iNPH grading scale evaluations of gait, cognition, urination and others	—

Countries

Japan

Contacts

Public ContactHiroaki Kazui

Kochi Medical School, Kochi University, Department of Neuropsychiatry

kazui@kochi-u.ac.jp088-880-2359

Outcome results