periodontitis
Conditions
Interventions
Transplantation of the processed cells
Administration of Enamel matrix derivative
Sponsors
Juntendo University
Juntendo clinical research and trial ceter, Juntendo hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A patient MUST: 1)Have a Periodontal pocket more than 5 mm at baseline examination. 2) Intrabony defect is 5 mm and more depth, and 2 mm and more width at interproximal site of the experimental tooth by X-ray examination. 3)Already have received initial preparation at the screening. 4)Mobility of experimental tooth is 0, 1, or 2, and exist keratinized gingiva. 5)Good oral health. 6)Subcutaneous fat tissue can be harvest normally and safely 7)20 years and older. 8)Signed informed consent.
Exclusion criteria
Exclusion criteria: Patient MUST NOT: 1)Can not be measured clinical attachment level of experimental tooth. 2)Have a history of Complicate malignant tumor. 3)Suspected of oral malignant tumor or precancerous lesion. 4)Have a history of usage bisphosphonate, or necessary. 5)Need to undergo the treatment, such as surgical treatment, restorative treatment or root canal treatment, at the experimental tooth within 36 weeks after transplant. 6)Pregnancy, during breastfeeding, or possibility of pregnancy. 7)Have disease of kidney, liver and/or blood. 8)Hemoglobin A1c is more than 6.8% at the screening. 9)Have active infectious diseases. 10)Alcoholism or Drug dependence. 11)Mental or consciousness disorder. 12)HCV antibody, HBs antigen, ATLA virus antibody or HIV antibody positive person. 13)Smoke more than 10 pieces per day. 14)Other,the investigator believes makes him/her unsuitable for participation in the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Validity and efficacy | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety | — |
Countries
Japan
Contacts
Public ContactMorikuni Tobita
Juntendo University Hospital Department of Oral and Maxillofacial Surgery
Outcome results
None listed