A Safety evaluation of risk-reducing mastectomy for BRCA1/2 pathological variant carriers

A Safety evaluation of risk-reducing mastectomy for BRCA1/2 pathological variant carriers - A Safety evaluation of RRM for BRCA1/2 pathological variant carriers

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000036134

Enrollment

Registered

2019-06-01

Start date

2019-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

BRCA1/2 pathological variant carriers

Interventions

Surgery : Risk-Reducing mastectomy

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1)BRCA1/2 pathological variant carriers 2)Woman without ipsilateral breast cancer occurrence 3)Woman who can visit our hospital to a follow-up survey after surgery 4)Informed consent

Exclusion criteria

Exclusion criteria: 1)Pregnant woman or possibility for pregnant woman 2)Physicaians concludes that the patient participation on this study in inappropriate.

Design outcomes

Primary

Measure	Time frame
safety of risk-reducing mastectomy	—

Secondary

Measure	Time frame
1)Incidence of breast cancer after risk-reducing mastectomy 2)Incidence of complications related risk-reducing mastectomy 3)Incidence of occult breast cancer and precancerous lesions	—

Countries

Japan

Contacts

Public ContactHirotsugu Yanai

Kansai Medical University hospital Department of surgery

hirotsugu_yanai@hotmail.com0728040101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026